In the time since the Vault Dweller's exile, a new government known as the New California Republic(abbreviated NCR) has begun to unify the southern towns and is spreading to the north. A mysterious new organization known as the Enclave has emerged with the most sophisticated technology in the wastes, even surpassing the Brotherhood of Steel. A new drug, jet, has become a cancer on many towns, its addictive properties forcing many to rely on the town of New Reno to keep them supplied.
The player eventually finds Vault 13 (the first place possible to obtain a GECK) devoid of the majority of its former human inhabitants. The Chosen One returns to find his village captured by The Enclave, which is later revealed to be remnants of the United States government. The player, through a variety of means, activates an ancient oil tanker and its autopilot, thus allowing him to reach the Enclave's main base on an offshore Oil Rig.
It is revealed that the dwellers of Vault 13 were captured as well, to be used as test subjects for FEV (Forced Evolutionary Virus), together with the Arroyo tribesmen. Vault 13 was supposed to be closed for 200 years as part of a Vault-Tec Vault experiment; this makes them perfect test subjects. The Enclave modified the Forced Evolutionary Virus into an airborne disease, designed to attack any living creatures with mutated DNA. With all genetic impurities removed, the Enclave (who remain protected from radiation) could take over.
The player frees both his village (Arroyo) and the Vault 13 dwellers from Enclave control, and destroys the Enclave's oil rig. In the ending, the inhabitants of Vault 13 and Arroyo villagers create a new prosperous community with the help of the GECK.
See also: FALLOUT 2 CHEATS & WALKTHROUGH